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Lewy bodies have also gained a lot of attention as to their specific distribution in neurons, and increases in their amount are consistent with both PD progression and neurodegeneration (Bethlem and Den Hartog Jager, 1984

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For example, LDloaded macrophages have been identified in human glioblastoma and were associated with an immunosuppressive state marked by increased CD39 and PD-L1 and reduced Major Histocompatibility Complex Class-II expression, suggesting that LD accumulation may support macrophage adaptation to the hostile tumor milieu while weakening anti-tumor immunity 148

doi: 10.1146/annurev-immunol-051116-052358, 34 DeepaS