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Furthermore, curcumin downregulates the expression of fibrogenic markers such as transforming growth factor-beta 1 (TGF-1), p38 mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), and the mammalian target of rapamycin (mTOR)

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Pubmed: 2564851 Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, et al.: Mch3, a novel human apoptotic cysteine protease highly related to CPP32

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