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Its deficiency decreases -KG, impairing JMJD3/UTX demethylase activity, increasing H3K27me3, and promoting the expression of apoptosis inhibitors such as XIAP and survivin [104]

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At subphysiological temperatures, neutrophil motility, phagocytosis, and neutrophil extracellular trap (NET) formation are markedly reduced (3739), and even mild perioperative hypothermia has been shown to increase the risk of surgical-site infections (19)

Lord C, Rutter M, Le Couteur A: Autism diagnostic interview - revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders