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In addition, Fer-1 alleviated DN and ameliorated renal hypertrophy and albuminuria by inhibiting ferroptosis, and ultimately reduced the accumulation of intracranial lipid peroxides in diabetic mice through the HIF-1/HO-1 pathway [242]

13 DHE staining revealed an increased ROS level in basilar membranes and ampullae of LPS-treated mice (Fig

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Glutathione content was measured in a 3 ml reaction mixture containing 0.2 mM NADPH, 100 mM phosphate buffer (pH 7.5), 5 mM EDTA