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Based on these findings, they advocate for clinical trials investigating the use of the epigenetic modulator RVX208 in PAH patients [114]

Similarly, MSH presented positive results in a model of renal fibrosis, induced by the administration of cyclosporine A, including reduction in TGF-1, inflammatory markers, cell apoptosis and collagen deposition (192)

doi:10.1016/j.freeradbiomed.2012.02.026, PMID: 22387197 Martn SF, Sawai H, Villalba JM, Hannun YA (2007) Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

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Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash M, Schroeder J, Kurnik M, et al