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once receptors are saturated, adding more is simply wasteful

If a lack of vitamin B12 prevents the brain from making these chemicals, you may experience common depressive symptoms, like: Anxiety Irritability Sadness Restlessness Additionally, a B12 deficiency can: Lead to increased amounts of the amino acid homocysteine, which can make depression worse [9]

Administration of NRN1 at graded doses (0.5, 1.0, and 1.5 g) significantly reversed STZ-induced cognitive deficits in both the novel object recognition and Morriss water maze tasks