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Table 33 Number of sub-visible particles in histidine-buffered cagrilintide and semaglutide co-formulations containing HP-B-CD of varying hydroxypropyl molar substitution degree Results for number of sub-visible particles are the mean of 3 replicates and have been rounded to nearest integer value 1 MS: molar substitution, corresponds to hydroxypropyls per glucose unit Concluding Remarks The results presented in table 33 show that the histidine-buffered co-formulations 33-37, comprising HP-B-CD with a wide range of molar substitutions (Average MS: 0.62- 0.92), remained physically stable for 28 days

J Biol Inorg Chem 31 , 239277 (2026)

Placenta 27(45):451458 Crider KS, Yang TP, Berry RJ, Bailey LB (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folates role

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For example, CNF-1 was reported to induce inflammatory responses and produce chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 3 (MIP-3) (Munro et al., 2004)