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Soil quality is declining due to intensive farming practices Early humans received plenty of B12 from the good quality (cobalt-rich) soil that was yet to be intensively farmed and drained of nutrients, and because they drank dirty ("natural") water from rivers which also contained B12 and B12 producing bacteria

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A 2018 review (9) also found that IV glutathione therapy and injections could cause the following, rare effects as well: Skin rashes Stevens-Johnson syndrome, a rare but serious disorder that affects mucous membranes

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