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Description

No peptide is currently FDA-approved specifically for PMOS treatment

In this modification, one of the non-bridging oxygen atoms in the phosphodiester bond is substituted with a sulfur atom (109)

Importantly, due to its ecto-enzymatic activity, CD38 not only regulates intracellular and extracellular NAD homeostasis, but also modulates the availability of extracellular NAD and its metabolites [6, 57]