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Immunoglobulin G (IgG) antibodies from FM subjects, when transferred into mice, induced FM-like symptoms 7 such as heightened sensitivity to painful stimuli and reduced intraepidermal nerve fiber density (IENFD), consistent with previous observations in FM patients 8

doi: 10.1016/0042-6822(91)90893-G 22 RickinsonA

107(6):771781 Endocrine and metabolic roles of insulin-like growth factor signaling in experimental models Sjgren K, Jansson JO, Isaksson OG, Ohlsson C., Minerva Endocrinologica , 2002

The proteomics data related to DeltaTag have been deposited in MassIVE with the following accession codes: MSV000096863, PXD059864 ( artificial modification of PDE by 5e ) and MSV000096865, PXD059867 ( artificial modification of PDE by 6a ), MSV000096867, PXD059870 ( phosphoproteomic profiling of 6a ), and MSV000096869, PXD059872 ( TPP of 6a )

Because nasal sprays are easy to use in everyday life, their ease of administration also makes research and treatment plans more convenient