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Using tissue from donors, the team observed that cells in the nucleus pulposus, a jelly-like structure at the center of intervertebral discs, had a lower amount of this peptide receptor when degeneration increased

A 2025 review by Araj and colleagues in the International Journal of Molecular Sciences described its geroprotective, antioxidant, and neuroprotective effects, while calling for more validation

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

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225 Inhibition of NETosis with PAD4 and DNase I inhibitors has shown promise in enhancing CD8 + T cell infiltration, reducing tumor growth, and improving the cellular response to anti-PD-1 blockade therapy in colorectal cancer