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This is the basis for high-dose oral B12 as an alternative to injections in patients who lack intrinsic factor

This can be caused by an underlying condition that affects one of your organs, such as: congestive heart failure where the heart is unable to pump enough blood around the body acute liver damage often caused by drinking excessive amounts of alcohol long-term dialysis where a machine that replicates the kidney function is used to filter waste products from the blood Medicine Some types of medicines reduce the amount of folate in your body or make the folate harder to absorb

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It gets even more important when you realize that vitamin B12 is vital for cellular energy production and detoxification systems via the glutathione pathway (1)

These ulcers are clinically and histopathologically identical to the lesions of aphthous stomatitis, but this type of oral ulceration is not considered to be true aphthous stomatitis by some sources