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Description

No FDA status Not FDA-approved Compound Semaglutide Mechanism GLP-1 receptor agonist

The study reported DNMT1 inhibition and depletion of SAM levels at doses, which had minimal effect on cell proliferation

Aging Cell 2020;19:e13094

Chopra P, Tinkle B, Hamonet C, Brock I, Gompel A, Bulbena A, Francomano C

Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A