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Specifically, the highly expressed K430la of ATP-binding cassette subfamily F member 1 (ABCF1) in HCC tissues enhances its nuclear localization, accompanied by its binding to the lysine demethylase 3A (KDM3A) promoter, leading to KDM3A upregulation and subsequent activation of the KDM3A-H3K9me2-HIF1A axis

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PMC 5630510