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It has been shown that T2DM impacts a variety of tissues [1] but previous studies have provided very little evidence of how T2DM alters the nutrigenomic responses to foods in specific tissues

Ajani JA, Correa AM, Walsh GL, Komaki R, Lee JH, Vaporciyan AA, Rice DC, Yao JC, Maru DM, Hofstetter WL, Phan AT, Swisher SG

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These findings are consistent with previous reports demonstrating the persistence of key driver mutations, such as TP53, after platinum-based NAC and highlighting substantial spatial intratumoral heterogeneity [26]