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There have been efforts to overcome these problems by modifying the drugs in different ways to circumvent these hindrance such as (1) isolate human native enzymes to reduce allergy, (2) isolate enzyme isoforms with higher specificities and efficiencies, (3) pegylate the enzymes to reduce allergy and prolong the half-lives, and (4) design drug combinations protocols to enhance the efficacy of chemotherapy by drug synergy and minimizing resistance

Eichenbaum, H

Tissue specimens were removed from 2.5% glutaraldehyde and then fixed with 1% osmium tetroxide

[DOI] [PubMed] [Google Scholar] 11.Ho D

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