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However, a clinical study reported that paclitaxel caused hypothyroidism in several patients, suggesting that paclitaxel can disrupt the hormonal balance (Mie, 2025)

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In addition, exposure to heavy metals (e.g., iron, lead, mercury, cadmium, arsenic, and Mn) and metal-based nanoparticles increases the risk of PD through the neurotoxic accumulation of metals in the SNpc and by increasing oxidative stress-induced apoptosis (Milatovic et al., 2009