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translation to oral dietary-supplement design requires caution due to route-dependent bioavailability and brain exposure differences

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In another study of schizophrenic patients (N=84), Berk et al 16 undertook a randomized, double-blind, placebo-controlled trial and found that NAC, administered at 1g twice daily for 24 weeks, was a moderately effective augmentation strategy and resulted in improvement in the study scales assessing positive and negative symptoms as well as overall functioning