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Because intracellular free Zn is toxic to the cell, under normal conditions, it is mostly bound to proteins such as metallothioneins (MTs), whose expression is induced by increased intracellular Zn [330]

Uttley AHC, Collins CH, Naidoo J, George RC

Furthermore, liver X receptors (LXRs) collaborate with PPAR in regulating hepatic and adipose lipogenesis during obesity and insulin resistance ( Table 4 )