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Ao T, Kikuta J, Ishii M

It modulates certain inflammatory pathways through GLP-1 and GIP receptor activation, reducing production of specific inflammatory cytokines like TNF-alpha and IL-6

Following increased permeability of the BBB, extravasated albumin is taken up into astrocytes (73), resulting in impaired buffering of potassium and glutamate, which may cause neuronal hyperexcitability and spontaneous seizures (74)

[ There is still a controversy whether high UA is a compensatory mechanism to overcome increased oxidative stress, which is an independent cause of cardiovascular disease [ and is a component of the inflammatory process