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Description

This work was supported by the National Natural Science Foundation of China (U23A20501, 82404816), the key research and development plan projects of Heilongjiang Province (2022ZX02C04), the Guangdong Basic and Applied Basic Research Found Project (2023A1515110703), the Traditional Chinese Medicine Bureau Of Guangdong Province (20254061), the State Key Laboratory of Dampness Syndrome of Chinese Medicine (SZ2021ZZ49, SZ2022KF16), the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(YN2024GZRPY017)

Stray 2005)

In detail, GH insensitivity (GHI) is characterized by low IGF-1 levels associated with normal or elevated GH levels and lack of IGF-1 response after GH administration ( Several genetic defects are responsible for the impairment of GH and IGF-1 actions, resulting in short stature that could be manifest during both the prenatal and postnatal period