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showed that SB administration (1 g/kg/d) inhibited the activation of the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway in a HDAC5/HDAC6-dependent manner, contributing to reducing Ang II-induced heart hypertrophy, mean arterial pressure and inflammation ( Nutting and Mortesen studies on arties showed that butyrate causes endothelial-dependent vasodilation in the arteries by increasing cyclic AMP (cAMP) levels (Table 3

However, apart from cross-linking its substrates, tTG can also hydrolyse peptide-bound glutamine to glutamic acid either at a lower pH or when no acceptor proteins are available, a process leading to an enhanced immunogenicity of gluten peptides [1,6] (Figure 1)

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The decrease in total protein content may be because LAB promoted protein degradation during fermentation to meet the bacterial needs for nitrogen-containing substances (35)