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Results: HFD-fed mice showed hepatic steatosis (H&E staining of liver sections), while fluorene exposure resulted in increased liver inflammatory infiltration

doi: 10.1210/jc.2019-00350 20 CheckJH

Abbreviations 3-PO: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one 5-FU: 5-fluorouracil AGS: Gastric adenocarcinoma cell line AML: Acute myeloid leukemia APC: Antigen-presenting cell ATO: Arsenic trioxide AUF: Auranofin BLAD: Bladder cancer BR: Breast cancer BSC: Best supportive care CLL: Chronic lymphocytic leukemia CRC: Colorectal cancer CSCs: Cancer stem cells Cmax: Peak serum concentration achieved DHA: Dehydroascorbic acid DLT: Dose-limiting toxicities Dox: Doxycycline d-TPP: TPP derivative dodecyl-TPP EMT: Epithelial-to-mesenchymal transition EPI: Epithelial ESI-FT ICR MS: Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry GB: Glioblastoma GBM: Glioblastoma multiform GC: Gastric cancer Gem: Gemcitabine HCC: Hepatocellular carcinoma HNC: Head and neck cancer ICI: Immune checkpoint inhibitors IR/RT: Irradiation/radiotherapy IVC: High-dose intravenous VitC JQ1: Thieno-triazolo-1,4-diazepine LC-MS/MS: Liquid chromatographymass spectrometry LEU: Leukemia LIP: Labile iron pool LUNG: Lung cancer LYM: Lymphoma MALDI-TOF MS: Matrix assisted laser desorption ionization-time of flight mass spectrometry mCRC: Metastatic colorectal cancer mEHT: Modulated electrohyperthermia MEL: Melanoma MES: Mesenchymal MM: Multiple myeloma MMR: Mismatch repair MoA: Mechanisms of action MTD: Maximum tolerated dose NB: Neuroblastoma NSCLC: Non-small-cell lung cancer OC: Orally administered VitC ORAL: Oral cancer ORR: Objective response rate OS: Overall survival OVC: Ovarian cancer Oxa: Oxaplatin PC: Prostate cancer PDAC: Pancreatic ductal adenocarcinoma PFS: Progression-free survival QoL: Quality of life RCC: Renal cell carcinoma RT: Radiation therapy SAR: Sarcoma SILAC: STABLE Isotope Labeling by/with Amino acids in Cell culture TET: Ten eleven translocation enzyme TETA: Triethylenetetramine TMZ: Temozolomide URI: Urinary cancers VitC: Vitamin C References Padayatty S, Levine M

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Enriched Pathobionts An overabundance of proinflammatory microbes may serve as a negative indicator