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The mechanism by which amylin slows gastric emptying is still unknown, but evidence from animal studies suggests that amylin may influence the efferent activity of the vagus nerve via neurons in the brainstem

To date, all these peptides have followed similar trajectories: promising animal data with no evidence of efficacy in humans, despite extensive advertising and widespread availability of these compounds to athletes, Ellis and colleagues wrote in their AOSSM article

Community-reported effects are generally described as mild e.g., fatigue, nausea, headache, or injection-site reactions

S., Boschero, A

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