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Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100

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Reduced plasma tryptophan and cerebrospinal serotonin levels further support this theory, forming the basis for SSRIs

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv fr Klinische und Experimentelle Ophthalmologie

Elevated expression of GPx8 is correlated with decreased patient survival and the establishment of an immunosuppressive microenvironment (Bai et al