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AMP-activated protein kinase (AMPK), a sensor of cellular energy status, plays an energy stress-mediated protective role against ferroptosis ( Figure 1 The Potential Role of Ferroptosis in Lupus Immunity Most immune cell types are implicated in SLE pathogenesis, beyond the activation of B cells ( T cells in lupus patients have been correlated with abnormal mitochondrial hyperpolarization and adenosine triphosphate (ATP) depletion, which cause predisposition to death by necrosis ( + and CD8 + T cells that lack GPX4 would rapidly accumulate membrane lipid ROS, and undergo ferroptosis, leading to their inability to expand and protect against viral and parasite infections ( B cells are the central elements of humoral immunity and protection due to their ability to produce antibodies

We highly encourage patients to contact our scheduling coordinators as early as possible to secure a convenient date that perfectly aligns with their ongoing treatment protocol

doi: 10.1016/j.immuni.2016.10.026 22 KrishnarajahSBecherB