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doi: 10.1038/eye.2015.64

So I do think that it's, you asked how I feel about it

Additionally, immune evasion remains a major challenge in ICI therapy

22 In the liver of WT mice, phosphorylation of JNK which is activated by TNF- was increased by Con A administration, whereas its phosphorylation did not increase in the liver of Gpx1 KO mice injected with Con A (Figure 3b)