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Pharmacological treatment with melatonin counteracted these effects by enhancing SIRT1 and PGC-1 activity, reducing Drp1 levels, lowering ROS production, and restoring mitochondrial and overall cardiac function [68]

demonstrated mean zones of inhibition in millimeters of 15.9 1.1, 19.3 2.2, 10.1 0.3, 12.8 2.3, 10.3 0.2 and 11 0.9, respectively

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