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In the most severe cases, neonatal presentation includes recurrent episodes of hypoketotic hypoglycaemic encephalopathy, liver dysfunction, often cardiac dysfunction, and sometimes congenital malformations

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395 In diabetic mouse models, Lactobacillus paracasei has been shown to reduce retinal inflammation, gliosis, neuronal cell death, and vascular capillary loss, thereby mitigating DR

Hypothyroid myopathy with unusually high serum creatine kinase values

Make sure you try the heroic red Listn Negro (family-owned vineyard Tajinaste in the Valle de la Orotava produces a particularly good one, as does Bodegas Monje with its 500-year old vines creating an intense, volcanic character), and round off lunch or supper with a glass of sweet and aromatic Malvasa wine (try Brumas de Ayosa Malvasa Dulce)