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Interestingly, the nematode enzyme shows a higher sequence identity to mammalian PGDS than to other parasitic worm Sigma class GSTs 22

However, despite recent reports of off-label uses that have popped up in the news over the past few months, the only FDA-approved use for methylene blue is for the treatment of methemoglobinemia, a rare condition that restricts the ability of red blood cells to deliver oxygen throughout the body

Hepatic artery reconstruction in rat LT can prevent bile duct ischemia and preserve the structure of the liver [50]

The mechanism appears to involve interaction with the endogenous opioid systemDSIP modulates enkephalin and beta-endorphin release, suggesting opioid-system cross-talk