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LR3 is a variant designed to reduce IGF-binding protein affinity , helping more ligand reach the IGF-1 receptor

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Micro Pathog 161:105272 Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW, Goddard ME, Wray NR, Visscher PM et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets