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10.1016/j.freeradbiomed.2018.01.012 149 KaberaJ

Breast cancer therapy with trastuzumab, an anti-ErbB2 monoclonal antibody, was shown to induce dilated cardiomyopathy and heart failure (Seidman et al., 2002), pointing to a role of NRG-1 signaling in cardiac remodeling

K.MatsumotoH

In human hepatoma and breast cancer cells, carbonylation inactivates the phosphatase and tensin homolog (PTEN) tumor suppressor which facilitates the activation of protein kinase B (PKB/Akt) that stimulates cell proliferation (84, 85)