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INO binds A2A receptors with lower affinity than ADO and preferentially activates ERK1/2 over cAMP signaling ( Targeting the CD38/NAD + axis remains an attractive immunotherapeutic strategy in MM, but the broad expression of CD38 raises concerns about off-target toxicity ( Supplementary Table 1 ), ADA-based degradation ( + surrogates ( Overall, our findings indicate that anti-CD38 therapies engage a dynamic, compartmentalized adenosinergic network in MM, with metabolic adaptations that may influence therapeutic responses

Patients with other severe electrolyte imbalances (e.g., hyponatremia, hypercalcemia) should have their condition corrected before diuretics, like hydrochlorothiazide

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doi: 10.1097/FPC.0b013e32832af5a3 55