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The small-molecule inhibitor MNPC potently targets both NQO1 and GSTP1, disrupting redox homeostasis, elevating ROS, and inducing apoptosis in EGFRvIII-mutant GBM cells

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K.ArpornchayanonW.JannaschK.AlvesF.et al (2010)

Specifically, AI applies machine learning algorithms to identify potential drug targets and elucidate mechanisms of action, offering new strategies for screening and validating antidepressant components in Chinese medicine [10]

LnaB and tested members of the S-HxxxE family catalyze protein AMPylation Incubation of 32 P--ATP with LnaB in the absence of PR-Ub generated radio-labeled LnaB (Fig