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A poor prognosis for hearing recovery has been identified in older patients, those with profound hearing loss, flat audiometric configurations, high-frequency loss, delayed treatment, the presence of vertigo, and cochlear enhancement on MRI [12, 98,99,100,101,102,103], The impact of diabetes and cardiovascular risk factors on recovery has shown conflicting results

1b) [26]

Indeed, it necessitates the activation of thiolate form of glutathione for direct glutathionylation reaction toward non-conjugated substrates (Dirr et al., 1997)

Supports Liver Detoxification Aids in removing toxins, heavy metals, and waste

Cette particularit explique pourquoi la NAC est tudie en priorit dans un contexte hpatique : le foie est la fois le lieu principal de sa mtabolisation et l'organe qui consomme le plus de glutathion