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Biochem J 326:305310 Jez JM, Cahoon RE (2004) Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana

Polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene lead to reduced methylation, elevation of Hcy, reduction of nitric oxide, microvascular disease- particularly capillary endothelial injury and apoptosis, microaneurysms, leakage, ischemia, retinal atrophy, neovascularization, and vision loss [22]

What I thought I'd do for the rest of the answer is go over what freckles are and how the F version of the MC1R gene causes them

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