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Complex IV, Cytochrome c oxidase

(92) conducted a 16-week randomized, double-blind, controlled trial with 196 patients, finding that omega-3 PUFAs significantly reduced the total number of migraine attacks compared to placebo, though a strong placebo effect was observed, and the study did not confirm earlier findings from smaller studies

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6.2 Mechanisms of action The antidepressant and neuroprotective properties of Ginkgo biloba are attributable to its multifaceted mechanisms of action (Figure 2)