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Cross-class GIP binding affinity retatrutide GIPR EC50 0.0643 nM (Coskun 2022) vs tirzepatide GIPR EC50 1.01 nM (Willard FS, et al

Johnston JD, Klosen P, Barrett P, Hazlerigg DG

(JD Supra) For clinics, prescribers, and compounders, the stakes are blunt: if PCAC and FDA say no, access shifts further to offshore suppliers and domestic gray-market sellers