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Additionally, following cisplatin exposure, nuclear factor-erythroid 2-related factor 2 (NRF2) activates MST4, which in turn phosphorylates protein arginine methyltransferase 5 (PRMT5) and binds to METTL3, leading to increased levels of METTL3-R36me2 and mRNA m6A methylation at the N6 position, thereby recruiting to DNA damage sites to promote RAD51-mediated homologous recombination repair

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