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Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

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A vitamin B12 deficiency can develop slowly and symptoms may include: Persistent tiredness or low energy Shortness of breath Pale skin Pins and needles Memory or concentration difficulties If left untreated, deficiency can lead to more serious neurological complications