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This has been demonstrated in multiple studies with rats and swine, where growth hormone levels significantly increased after injections without impacting ACTH and cortisol plasma levels: In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml)

[Abstract]2022 Sep;150(3):727-735.e6

Ipamorelin should only be used with provider guidance and monitoring

Many protocols favor dosing at night, since that aligns with your largest natural pulse of growth hormone during deep sleep

You should avoid or use the medication with caution if you have: Active malignancy (cancer) Proliferative retinopathy (serious eye disease) Pregnancy, or if you are breastfeeding Severe obesity with sleep apnea (higher risk of complications) Allergy to any ingredient in the medication Untreated hypothyroidism can cause a sluggish thyroid, which can reduce the effectiveness of Sermorelin, leading to limited or poor results