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[11] Each domain individually is very similar to the analogous domains in glutathione reductase and lipoamide dehydrogenase, but the relative orientation of these domains in ThxR is rotated by 66 degrees

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This implies that LRRK2 kinase activity regulates GCase in a cell-type specific manner, as neurons derived from individuals with LRRK2 PD show reduced GCase activity which can be rescued by inhibition of LRRK2 kinase activity via MLi-2 211

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