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Analogous to macrophages, fibroblasts can initiate pro-inflammatory signaling pathways to facilitate leukocyte recruitment and regulate their activity 43

SCFA, key metabolites derived from the microbial fermentation of dietary fibers, include acetate, propionate, and butyrate

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Conventionally, this includes CpG methylation, histone modification or marking, and gene imprinting, but recent evidence shows that small RNAs could also play a critical role in directing epigenetic silencing