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Due to the lengthy duration of treatment and adverse side effects, there is a high drop-out rate from DOTS therapy

Other rodent models also corroborate a salutary response to GABA in diabetes(median dose 1500 mg/kg/day, range 0.25-4500) (4452)

High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition: the PRIME post-COVID study

The PFC and CC have been identified as principal areas involved in mood disorders (4, 23), and their myelin content could be considered an important indicator of depression (20, 24)