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33,38,42,44,46,47 In line with these observations, mathematical modelling using data from treatment-nave patients predicted that the primary tumours and their metastases share the same driver mutations

The TCA cycle is completed by MDH, which, as a salt-sensitive enzyme, is thought to play a protective role by counteracting the damaging effect of salt by increasing the malate through conformational change (Saha et al., 2012)