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To induce colitis, all groups except the NC group received 3.0% (w/v) dextran sulfate sodium (DSS) dissolved in sterile drinking water ad libitum for 7 days, while the NC group received sterile drinking water only

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The previous consensus was that cell growth in G1 drove a gradual increase in cyclin D-CDK4/6 activity which eventually activated the E2F-dependent transcription of the downstream cyclins E and A that complete Rb hyperphosphorylation 1214

Study characteristics extracted included study design, intervention, number of patients in each arm of the study, treatment duration and follow up period