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Disclosure The authors declare no conflicts of interest in this work

IgM responses have often been underestimated and assumed to be part of a transient immunity preceding the development of high-affinity IgG

The most significant data comes from the REDEFINE trials, evaluating the co-administration of Cagrilintide and Semaglutide These findings highlight the synergistic potential of combining the amylin pathway (Cagrilintide) and the GLP-1 pathway (Semaglutide) to achieve superior metabolic and weight loss outcomes compared to either agent alone