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Rev Drug Discov

Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, et al

TXNIP is also transcriptionally regulated in a cell type-specific manner by nuclear receptors such as peroxisome proliferator-activated receptor (PPAR), farnesol X receptor, vitamin D receptor and glucocorticoid receptor (50)

For patients already on injections, this is what the dosage translation looks like: 0.250.5 mg injection start 4 mg or 9 mg pill for 30 days 1.0 mg injection start 9 mg pill for 30 days 1.7 mg injection start 9 mg pill, then titrate to 25 mg after 30 days 2.4 mg injection (max dose) stop injection, wait 7 days, then start 25 mg pill Note: There is *no direct milligram-to-milligram equivalence* between injections and pills

Titration schedule above reflects the standard RxPepsDirect protocol