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The most parsimonious hypothesis is simply that this is a case of a viral protease targeting a cellular gene for cleavage, for which there are abundant precedents, including the proposed M pro targeting of TRMT1 and HDAC2 ( Functional Effects of M PRO in Transfected Cells are Consistent With GPX1 Knockdown As detailed above, the original 2003 SCoV M pro has essentially identical substrate sequence specificity as that of SCoV2

Bajt ML, Ho YS, Vonderfecht SL, Jaeschke H

Thus, reduced BMAL1 expression in the ChP does not disrupt the maintenance of basal physiological rhythms in mice

The significant increase in SOD activity associated with the decrease in plasma ceruloplasmin, antioxidant vitamins and the whole blood GPX activity in protein energy malnourished children suggest that these children are potentially susceptible to high oxidative stress

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