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1st Edition Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases By Luc Montagnier, Rene Olivier, Catherine Pasquier Copyright 1998 576 Pages by CRC Press 576 Pages by CRC Press 576 Pages by CRC Press Also available as eBook on: Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity

Exogenous ROS can be generated by environmental pollutants, such as heavy metals ( When ROS levels are elevated, glioma cells initiate their own antioxidant defence system in response to oxidative stress (OS)

Thus, summarizing, ferroptosis is basically system Xc inhibition dependent and driving a process that culminates in the fat-induced final lethal step of the lipid peroxidation and GPX4 play a prominent protective role in it